Technology


EchoSense develops an innovative technology and device platform, the Transthoracic Parametric Doppler (TPD) designed to provide diagnosis of a number of major cardio-pulmonary diseases. The TPD is a portable, simple to operate, non-invasive ultrasound Doppler system that provides diagnoses rather than an image that has to be interpreted by a specially trained physician.

How It Works

The TPD system does not involve imaging and therefore does not depend on the exact positioning of the ultrasound probe. Moreover, it is relatively insensitive to interference by the chest bones or probe instability. Measurement Capabilities: The TPD system measures Doppler signals directly from the lungs. These signals reflect on the mechnical events of the different cardiac components (ventricles, atria). Traditionally this capability was considered unattainable in view of the extremely high ultrasound attenuation by the air in lungs. An example of the Doppler signals recorded over the right lung are shown in the diagram below.

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The Lung Doppler Signals (LDS)

During each cardiac cycle, the recorded tracing typically consists of three distinct signals that have a striking unique feature. Each signal consists of synchronous positive and negative component, i.e. reflecting simultaneous ultrasound reflection (from the interface between the alveolar air and blood vessels) movements in opposite directions. This unique feature provides insight into the pulmonary blood vessel wall characteristics as well as the pressure pulsations originating at the heart.

Signal Analysis

The signals are synchronous with the various basic elements of cardiac cycle (note the R waves in the ECG). Signal S represents ventricular systole, signal D the diastole while signal A is linked to atrial contraction. The velocity and power characteristics of these signals contain information regarding a number of very significant cardio-pulmonary characteristics: cardiac contractility, the compliance of the pulmonary blood vessels and the level of ultrasound attenuation by the lung parenchyma and alveoli. The latter change with fibrosis, emphysema, pulmonary edema, etc.

Summary

EchoSense has developed an innovative fully automated signal analysis application that extracts various features from the Lung Doppler Signals to provide unique enhanced diagnosis capabilities. The TPD device is simple to operate and is based on a non-invasive method of diagnosis that does not require a specially trained physician.